Although cyclophosphamide and corticosteroids have effects on B-cells, the advent of B-cell directed therapies using specific antibodies against CD20, CD22, and against B-cell survival factors and cytokines (anti-BAFF, anti-BR3, TACI-Ig, anti-IL10, anti-IL6), or agents modulating B-cell receptor strength (LJP394, Epratide) provide different mechanisms of action, potential different efficacies and different adverse events

Although cyclophosphamide and corticosteroids have effects on B-cells, the advent of B-cell directed therapies using specific antibodies against CD20, CD22, and against B-cell survival factors and cytokines (anti-BAFF, anti-BR3, TACI-Ig,…

Significantly, an assortment of two mAbs to HER2, pertuzumab and trastuzumab, in conjunction with chemotherapy, considerably prolonged progression-free survival of breast cancer patients whose tumors overexpress HER2 (8)

Significantly, an assortment of two mAbs to HER2, pertuzumab and trastuzumab, in conjunction with chemotherapy, considerably prolonged progression-free survival of breast cancer patients whose tumors overexpress HER2 (8). capability of…