These observations could be interpreted as evidence that Foxp3+ Treg cells are dispensable for the autoimmune cell protection in the NOD model, but the interpretation of data in the constitutive absence of Treg cells is usually hampered by potentially confounding effects of immune adaptations and severe systemic autoimmunity, including premature death and alterations in thymic T cell development (12)

These observations could be interpreted as evidence that Foxp3+ Treg cells are dispensable for the autoimmune cell protection in the NOD model, but the interpretation of data in the constitutive…

The expression degrees of GITRL, but notably also of several other immunoregulatory substances like NK inhibitory HLA class I, will determine if the amount of activating signals is enough to induce relevant NK reactivity against these healthy cells or not

The expression degrees of GITRL, but notably also of several other immunoregulatory substances like NK inhibitory HLA class I, will determine if the amount of activating signals is enough to…

We hypothesized that this effect can also be present in DCs, since IL-10 has autocrine signaling in DCs, preventing the migration toward regional lymph nodes, precluding antigenic control and demonstration, as observed in mycobacteria

We hypothesized that this effect can also be present in DCs, since IL-10 has autocrine signaling in DCs, preventing the migration toward regional lymph nodes, precluding antigenic control and demonstration,…