These observations could be interpreted as evidence that Foxp3+ Treg cells are dispensable for the autoimmune cell protection in the NOD model, but the interpretation of data in the constitutive absence of Treg cells is usually hampered by potentially confounding effects of immune adaptations and severe systemic autoimmunity, including premature death and alterations in thymic T cell development (12)

These observations could be interpreted as evidence that Foxp3+ Treg cells are dispensable for the autoimmune cell protection in the NOD model, but the interpretation of data in the constitutive…