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[PubMed] [Google Scholar] 8. for assist in manuscript formatting. This function is certainly backed by NIH grants or loans AI079031 and AI080916 (to M.L.), AI071084 (to D.R.B.), AI084817 and U54 GM094586 (to I.A.W.), as well as the Skaggs Institute (I.A.W.). L.K. is certainly grateful towards the American Base for AIDS Analysis to get a Mathilde Krim Fellowship in Simple Biomedical Analysis and R.U.K. towards the Swiss Country wide Science Base to get a post-doctoral fellowship. The EM data had been collected at the united states Country wide Reference for Automated Molecular Microscopy (NRAMM) on the Scripps Analysis Institute, which is certainly supported by the united states Country wide Institutes of Wellness (NIH) through the Country wide Center for Analysis Assets’ P41 plan (RR017573) on the Country wide Center for Analysis Assets. X-ray data models were collected on the Stanford Synchrotron Rays Lightsource (SSRL) beamline 12C2, a Directorate from the SLAC Country wide Accelerator Lab and an Workplace of Research Consumer Service controlled for the U.S. Department of Energy (DOE) Office of Science by Stanford University. The SSRL Structural Molecular Biology Program is supported by the DOE Office of Biological and Environmental Research; NIH’s National Center for Research Resources, Biomedical Technology Program (P41RR001209); and the National Institute of General Medical Sciences (NIGMS). Coordinates and structure factors for the LAMB3 E2c complex with Fab AR3C have been deposited with the Protein Data Bank under accession code 4MWF. The EM reconstruction densities for the E2TM-Fab AR3C, E2TM-Fab AR3C-Fab AR2A, and E2TM-FabAR2A-CD81 LEL complexes have been deposited with the Electron Microscopy Data Bank under accession codes EMD-5759, EMD-5760 and EMD-5761 respectively. The content is the responsibility of the authors and does not necessarily reflect Naspm trihydrochloride the official views of the NIGMS, NCI or NIH. This is manuscript #24038 from The Scripps Research Institute. Footnotes The authors declare no competing financial interests. References and Notes 1. Choo QL, et al. Isolation of a cDNA clone derived from Naspm trihydrochloride a blood-borne non-A, non-B viral hepatitis genome. Science. 1989;244:359. [PubMed] [Google Scholar] 2. Lavanchy D. The global burden of hepatitis C. Liver Internat. 2009;29:74. [PubMed] [Google Scholar] 3. Ly KN, et al. The increasing burden of mortality from viral hepatitis in the United States between 1999 and 2007. Ann. Intern. Med. 2012;156:271. [PubMed] [Google Scholar] 4. Kuiken C, Hraber P, Thurmond J, Yusim K. The hepatitis C sequence database in Los Alamos. Nucleic Acids Res. 2008;36:D512. [PMC free article] [PubMed] [Google Scholar] 5. Houghton M, Abrignani S. Prospects for a vaccine against the hepatitis C virus. Nature. 2005;436:961. [PubMed] [Google Scholar] 6. Billerbeck E, de Jong Y, Dorner M, de la Fuente C, Ploss A. Animal models for hepatitis C. Curr. Top. Microbiol. Immunol. 2013;369:49. [PubMed] [Google Scholar] 7. Kuiken C, Simmonds P. Nomenclature and numbering of the hepatitis C virus. Methods Mol. Biol. Naspm trihydrochloride 2009;510:33. [PubMed] [Google Scholar] 8. Law M, et al. Broadly neutralizing antibodies protect against hepatitis C virus quasispecies challenge. Nat. Med. 2008;14:25. [PubMed] [Google Scholar] 9. Broering TJ, et al. Identification and characterization of broadly neutralizing human monoclonal antibodies directed against the E2 envelope glycoprotein of hepatitis C virus. J. Virol. 2009;83:12473. [PMC free article] [PubMed] [Google Scholar] 10. Keck ZY, et al. Naspm trihydrochloride Human monoclonal antibodies to a novel cluster of conformational epitopes on HCV E2 with resistance to neutralization escape in a genotype 2a isolate. PLoS Pathog. 2012;8:e1002653. [PMC free article] [PubMed] [Google Scholar] 11. Michalak JP, et al. Characterization of truncated forms of hepatitis C virus glycoproteins. J. Gen. Virol. 1997;78:2299. [PubMed] [Google Scholar] 12. Krey T, et al. The disulfide bonds in glycoprotein E2 of hepatitis C virus reveal the tertiary organization of the molecule. PLoS Pathog. 2010;6:e1000762. [PMC free article] [PubMed] [Google Scholar] 13. Whidby J, et al. Blocking hepatitis C virus infection with recombinant form of envelope protein 2 ectodomain. J. Virol. 2009;83:11078. [PMC free article] [PubMed] [Google Scholar] 14. Yagnik AT, et al. A model for the hepatitis C virus envelope glycoprotein E2. Proteins. 2000;40:355. [PubMed] [Google Scholar] 15. Materials and methods, and supplementary.